The Indian Council of Medical Research (ICMR) said that nasal swabs and throat swabs which are most widely accepted as the preferred method for obtaining respiratory samples to detect the presence of SARS CoV2 has certain disadvantages and could be overcome by gargling.
A study done to assess the agreement between gargle lavage and swab as an appropriate respiratory sample for the detection of SARS-CoV-2 has thrown up interesting results. This study was also done to assess the patient acceptability of the two sampling methods.
A cross-sectional study was done at a tertiary care hospital in New Delhi, (at Delhi's AIIMS) on 50 confirmed COVID-19 patients. Paired swab (NPS and OPS) and gargle samples were taken within 72 hour of diagnosis. Samples were processed by reverse transcription-polymerase chain reaction (RT-PCR) for detection of SARS-CoV-2. Post-sample collection, a 10-point scale was administered to assess the level of discomfort with either of the collection methods.
It was found that all gargle samples were positive and comparable to their corresponding swab samples, irrespective of the symptoms and duration of illness.
A majority (72%) of the patients reported moderate-to-severe discomfort with swab collection in comparison to 24 per cent reporting only mild discomfort with gargle collection.
Importantly, the conclusion that has been arrived at is that the gargle lavage may be a viable alternative to swabs for sample collection for the detection of SARS-CoV-2.
The ICMR says this is crucial because it will enable easy self-collection, relieve healthcare workers and also lead to substantial cost savings by reducing the need for swabs and personal protective equipment.
Gargle is an easy-to-perform procedure, can be performed by the patients themselves without much training and may have better patient acceptability. The adoption of gargle for sample collection will translate to substantial cost savings as it would cut down not only the need for swabs and personal protective equipment (PPE) but also the need to develop and maintain special infrastructure for swab collection, says the ICMR in its study, now published in IJMR.
