Khan, 43, took to Instagram and informed her followers that she tested positive for COVID-19 on Monday evening.
She advised people to take precautions against the Omicron variant as it was extremely "contagious".
"After dodging COVID-19 for two years, in the 3rd year of 2022 the stubborn Omicron variant has finally infiltrated my immune system. I tested positive last night. Please be safe and take care of yourselves diligently.
"This is a very contagious one. #Willfightthis," Susanne Khan, who is the ex-wife of actor Hrithik Roshan, wrote on Instagram.
According to the Union health ministry data updated on Tuesday, India logged 1,68,063 new coronavirus infections taking the total tally of COVID-19 cases to 3,58,75,790 which includes 4,461 cases of the Omicron variant.