A massive explosion took place at a building in central Madrid on Wednesday afternoon, creating panic in the area with debris covering the street below.

As per reports, several people were injured in the unprecedented explosion. Fire tenders and ambulances have reached the scene and began ops.

"Nine fire crews and 11 ambulances have gone to Calle Toledo following an explosion in a building," local emergency services tweeted.

The cause of the blast it not yet ascertained.